In this paper, the key genes and the phosphorylation of PERK and downstream factors which involve in the ER-associated degradation pathway was notably reduced by JT003 in both NASH and liver fibrosis models, suggesting the ER-mitochondrial axis homeostasis disruption induced apoptosis and DNA damage were lessened significantly. The gene discussed is EIF2AK3; the disease is metabolic dysfunction-associated steatohepatitis.