As IL-10, IL-6 and TNFα was higher in the febrile phase in those who proceeded to develop DHF and since it has been reported that IL-1β is also associated with increase in vascular permeability28, we evaluated the usefulness of these 4 cytokines in a large cohort of patients who proceeded to develop varying degree of clinical disease severity. Here, IL1B is linked to Dengue hemorrhagic fever.