From the trend difference between groups A and C, we could differentiate noninfected-active SLE visits (group C) from infected-active SLE visits (group A) by the change patterns of ESR (mm/h), NLR, lymphocyte percentage, C3 (mg/dL), and C4 (mg/dL) over time. This evidence concerns the gene ESR1 and systemic lupus erythematosus.