Multivariate GEE analysis showed that SDI score, fever temperature (°C), CRP level (mg/dL), PCT level (ng/mL), lymphocyte percentage, NLR, Hb level (g/dL), and SLEDAI 2 K renal score were independent parameters for predicting acute infection in SLE patients (Table 5). The gene discussed is CRP; the disease is systemic lupus erythematosus.