BDNF and Alzheimer disease: We also demonstrated that Acanthoside B regulates cholinergic function by enhancing AchE inhibitory activity, attenuates oxidative stress and inflammatory cytokines, and activates the neurotrophic tropomyosin receptor kinase B/cAMP response element binding/brain-derived neurotrophic factor (TrkB/CREB/BDNF) pathway28, which are all processes involved in the key pathomechanism of both AD and VD.