Bacteria-driven oncogenic mechanisms in CRC have been proposed to include the activation of Wnt signaling (enterotoxigenic Bacteroides fragilis (ETBF)5 and Fusobacterium species6), proinflammatory signaling (Enterococcus faecalis7 and Streptococcus gallolyticus8), and genotoxicity (colibactin-producing Escherichia coli, colB + E. The gene discussed is SALL2; the disease is colorectal carcinoma.