FGF4 and neoplasm: Since the duplicated region identified in quadruple WT GISTs is involved at least two neighbouring TADs8, it is possible that the resulting neo-TAD formation allowed for the interaction with the ANO1 super-enhancer inducing the aberrant expression of FGF4. Further studies are needed to confirm this hypothesis; however, the extreme rarity of these tumours, the extensive molecular characterization already performed and the lack of appropriate cellular models hamper the development of deeper analyses on this aspect.