Since the duplicated region identified in quadruple WT GISTs is involved at least two neighbouring TADs8, it is possible that the resulting neo-TAD formation allowed for the interaction with the ANO1 super-enhancer inducing the aberrant expression of FGF4. Further studies are needed to confirm this hypothesis; however, the extreme rarity of these tumours, the extensive molecular characterization already performed and the lack of appropriate cellular models hamper the development of deeper analyses on this aspect. Here, ANO1 is linked to neoplasm.