All but one class II amplicon co-amplified at least one CRC-driven enhancer element distal of MYCN. Some of these enhancers were recurrently found on class II amplicons, including an enhancer 1.2 Mb downstream of MYCN that was co-amplified in 20.8% (5/24) of MYCN-amplified neuroblastomas, 2.1-fold higher than expected for randomized amplicons that include MYCN but not e4 (Fig. 3f). The gene discussed is MYCN; the disease is neuroblastoma.