By contrast, ATPsynβ knockdown in Hipk tumor-like cells not only generated high ROS (Fig. 5F), but also potentiated JNK activation and MMP1 upregulation across the entire Hipk-expression domain (Fig. 7D,G), and the effects seemed both additive and synergistic because ATPsynβ-RNAi on its own induced mild JNK phosphorylation (Fig. 7F). The gene discussed is MAPK8; the disease is neoplasm.