To find out whether the mitochondrial changes in Hipk tumor-like cells are linked to upregulation of Myc or Pfk2, we used RNAi to knock down Myc and Pfk2 individually in hipk-overexpressing wing discs and focused on transgene-expressing DP cells on the basal side of wing discs. The gene discussed is PFKFB3; the disease is neoplasm.