Earlier, we showed that Hipk tumor-like cells manifested Myc-driven Warburg effect (aerobic glycolysis)-like metabolic changes, including increased glucose uptake and transcriptional activation of glycolytic genes (e.g. encoding phosphofructokinase-2; pfk2, also known as pfrx) (Wong et al., 2019). The gene discussed is PFKFB3; the disease is neoplasm.