Given that high ROS potentiates JNK-dependent MMP1 induction (Fig. 7), most of the RNAi lines tested (ATPsynβ-RNAi, sdhC-RNAi and cox5A-RNAi) need to be accompanied by simultaneous overexpression of ROS scavengers in order to reduce Hipk tumor growth (Fig. 6). The gene discussed is MAPK8; the disease is neoplasm.