For example, loss of the mammalian NDUFB10 (pdsw in Drosophila) reduces the growth of K-RAS tumors (Martin et al., 2017), whereas low expression of NDUFS1 (which encodes another Complex I subunit) is correlated with poor prognosis and metastasis in non-small cell lung cancer patients (Su et al., 2016). The gene discussed is NDUFS1; the disease is non-small cell lung carcinoma.