VEGFA and neoplasm: The accumulation of malignant ascites is mediated by VEGF, a pivotal proangiogenic factor, which is known to be mainly secreted from tumor cells.12 45 46 Excessive VEGF in the peritoneal cavity promotes robust tumor angiogenesis both on the peritoneal surface and within the peritoneal tumor nodules, generating a myriad of hyperpermeable tumor neovessels.4 12 In the present study, intraperitoneal JX treatment effectively suppressed the malignant ascites formation within the peritoneal cavity through multiple mechanisms.