In this study, using ddPCR performed on routine diagnostic biopsies obtained from oesophagogastric cancer patients treated in the REAL3 trial, we identify a 7% prevalence of patients with EGFR-amplified tumours, which is consistent with the literature.1–3 We demonstrate that EGFR analysis in plasma is complementary to EGFR amplification detection in tumour tissue, and EGFR amplification appears associated with poor prognosis, even though these data are not statistically significant likely due to the small number of EGFR-amplified cases. Here, EGFR is linked to neoplasm.