KCNN4 and cancer: From The Cancer Genome Atlas database, other cancers that appear to significantly overexpress KCa3.1 mRNA relative to healthy tissue include cholangiocarcinoma (4.2-fold), kidney renal clear cell carcinoma (4-fold), lung adenocarcinoma 9.3-fold), pancreatic adenocarcinoma (6.1-fold), and, strongest of all, thyroid carcinoma (27-fold).