That KCa3.1 appears to be functionally upregulated in cervical cancer cells is further supported by our data showing a substantially increased occurrence of SKA 31 and TRAM 34-sensitive K+ currents and K+-mediated hyperpolarization responses in cancer cells relative to cervical epithelial cells obtained from the ectocervix and TZ of healthy tissue. The gene discussed is KCNN4; the disease is cervical cancer.