In collaboration with the biochemical laboratories, a high LDL could automatically be accompanied by a marker stating that individuals with a high LDL should be suspected of FH and family investigation considered.27,33 Similarly, an electronic message could automatically be forwarded to the general practice by the electronic patient record system whenever a diagnosis of, for instance, MI, ischaemic heart disease, or stroke is registered to an individual aged <55–60 years in order to identify potential FH and initiate cascade screening. The gene discussed is FH; the disease is Stroke.