This is reasonable since RNF39 is located in close proximity to the HLA-J (Major Histocompatibility Complex, Class I, J) locus on chromosome 6p22, a pseudogene of HLA-A (Major Histocompatibility Complex, Class I, A), and genetic variants in this region have been shown to be associated with insulin resistance in childhood obesity [41] as well as non-obstructive coronary artery disease in women [42]. This evidence concerns the gene HLA-A and Insulin resistance.