Furthermore, in the subgroup analysis, patients in the high-risk group tended to show higher AFP, higher AST, higher PLR, larger tumor size, more hemorrhage, more intraoperative transfusion, the presence of MVI and an incomplete tumor capsule, which are demonstrated prognostic indicators of HCC [38, 39, 55, 56], indicating the potential association between the radiomics signature and clinicopathologic factors. The gene discussed is AFP; the disease is neoplasm.