Further investigation revealed these dysregulated miRNAs controlled several signaling pathways, which are pivotal in the pathogenesis of IDD, such as Wnt [19, 26, 27], phosphoinositide 3-kinase/Akt (PI3K/Akt) [19, 28], and mitogen-activated protein kinase (MAPK) [19, 29], etc. Consistently, Hu et al. demonstrated that among the 253 miRNAs detected both in IDD and scoliosis samples, three were downregulated and six were upregulated in degenerative samples. The gene discussed is AKT1; the disease is scoliosis.