Further investigation revealed these dysregulated miRNAs controlled several signaling pathways, which are pivotal in the pathogenesis of IDD, such as Wnt [19, 26, 27], phosphoinositide 3-kinase/Akt (PI3K/Akt) [19, 28], and mitogen-activated protein kinase (MAPK) [19, 29], etc. Consistently, Hu et al. demonstrated that among the 253 miRNAs detected both in IDD and scoliosis samples, three were downregulated and six were upregulated in degenerative samples. This evidence concerns the gene AKT1 and intervertebral disk degenerative disorder.