FOXO1 and intervertebral disk degenerative disorder: Three deregulated miRNAs (miR-140-5p targeting TLR4 [85], miR-486-5p targeting FOXO1 [46] and miR-146a targeting TRAF6 [22, 80]; all studying in NP cells) are associated with decreased levels of inflammation, whereas three miRNAs (miR-221 targeting ERα in CEP cells [52], miR-640 targeting LRP1, β-catenin and EP300 in NP and AF cells [84], and miR-2355-5p targeting ERFFI1 in NP cells [62]) are linked with increased levels of inflammation during IDD.