Similarly, the expression of miR-21 [36], miR-499a-5p [40], miR-486-5p [46], miR-125a [51], miR-145 [56], and miR-573 [57] are decreased in IDD, which act as apoptosis inhibitors via binding to the 3′UTRs of mRNAs of PTEN, SOX4, FOXO1, TP53INP1, ADAM17, and Bax, respectively. Here, FOXO1 is linked to intervertebral disk degenerative disorder.