Similarly, the expression of miR-21 [36], miR-499a-5p [40], miR-486-5p [46], miR-125a [51], miR-145 [56], and miR-573 [57] are decreased in IDD, which act as apoptosis inhibitors via binding to the 3′UTRs of mRNAs of PTEN, SOX4, FOXO1, TP53INP1, ADAM17, and Bax, respectively. The gene discussed is PTEN; the disease is intervertebral disk degenerative disorder.