SIRT6 and thyroid gland papillary carcinoma: In addition, high expression of SIRT6 was associated with lymph node metastasis of colorectal cancers and thyroid papillary carcinomas [12, 15] and was associated with poor prognosis of breast cancer, ovary cancer, gastric cancer, lung cancer, and diffuse large B-cell lymphoma patients [14, 16–19].