Increased AIP value (per 1-unit) was consistently associated with the primary endpoint in different subgroups, including age < 60 versus ≥60 years, female versus male sex, BMI < 28 versus ≥28 kg/m2, LDL-C ≤ 1.8 versus > 1.8 mmol/L, with versus without hypertension, and non-ST versus ST segment elevation ACS (Fig. 2). The gene discussed is AIP; the disease is Hypertension.