GSEA results suggested that these MAGs might be involved in signal pathways such as regulation of proteolysis involved in cellular protein catabolic process (CLU/HSP90AB3P/MDM2/OS9/RNF180/SDCBP/TRIB2), p53 signaling pathway (CASP3/CCND2/CDK4/CDKN1A/IGFBP3/MDM2), transcriptional misregulation in cancer (CCND2/CDKN1A/IGFBP3/MDM2/PLAT/ZEB1) and JAK-STAT signaling pathway (CCND2/CDKN1A/FHL1/GFAP/STAT1). This evidence concerns the gene IGFBP3 and cancer.