Complementary to the data from ICC-based studies, there were two studies using RT-PCR for CK-20 [24] detecting 33% positive cases in a cohort of resectable PDAC [24] and CK-19 [25], detecting 67% positives in a cohort of mixed stage cases [25] (see also Table 3). Here, KRT19 is linked to intrahepatic cholangiocarcinoma.