Present study revealed that there was a strong positive correlation between ferritin and FGF23 in our patients with thalassemia, it could be suggesting another possible mechanism by direct stimulatory effect of ferritin on FGF23 secretion, which should be more investigated in future studies.As the result of a strong positive correlation between ferritin and FGF23 in our patients with thalassemia, another possible mechanism could be the direct stimulatory effect of ferritin on FGF23 secretion, which should be further investigated in future studies. The gene discussed is FGF23; the disease is thalassemia.