Meanwhile, in the 12 vs 16 months group, the top five canonical pathways activated by the differentially expressed miRNAs were PI3K signaling, iCOS-iCOSL signaling, inhibition of angiogenesis by TSP1, non-small cell lung cancer signaling, and telomerase signaling (Table 3). The gene discussed is ICOSLG; the disease is non-small cell lung carcinoma.