Early preclinical studies on venetoclax had shown potent cytotoxic activity in a subset of NHL cell lines, including not only FL, but also DLBCL and MCL, and these findings were replicated in xenograft models of DLBCL [44] and aggressive progenitor-cell lymphomas derived from bitransgenic MYC/BCL2 mice [73]. This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.