Specifically, we observed an early rise of the pro-inflammatory cytokine TNF-α and MHC-II, but not the anti-inflammatory cytokine IL-10, which instead displayed some reduction, indicating a disbalance in cytokine production, and suggesting that microglia acquired a pro-inflammatory profile after the interaction with H-αsynO, resembling PD neuropathology. The gene discussed is IL10; the disease is Parkinson disease.