NFE2L2 and type 2 diabetes mellitus: Moreover, metformin, a drug commonly used in the therapy of type 2 diabetes, decreases mRNA and protein concentrations of Nrf2 via the block of Raf/ERK/Nrf2 signaling [118], while IM3829 (4-[2-Cyclohexylethoxy] aniline) reduces Nrf2 mRNA and protein concentrations, and combination with radiation is capable to considerably block tumor survival [162].