As ASOs are by nature bulky and polar molecules that crucially depend on a suitable delivery vehicle, Arranz et al. used an ASO incorporated in amphoteric liposomes, nov038/CD40, which was intravenously injected into Balb/c mice that had been subjected to the induction of colitis by rectal administration of 2,4,6-Trinitrobenzenesulfonic acid (TNBS) [99]. Here, CD40 is linked to colitis.