Phosphoproteomic analysis resulted in the identification of 63 phosphosites on 50 proteins as cancer-associated phosphosites and showed that Rb, a known tumor suppressor is phosphorylated in colon cancer and its phosphorylation is associated with increased proliferation and decreased apoptosis, therefore suggesting Rb phosphorylation as a driver and therapeutic target in colon cancer [68]. This evidence concerns the gene RB1 and cancer.