Moreover, Tape and colleagues used heterocellular multivariate phosphoproteomics to investigate the oncogenic KRAS (KRASG12D) cell-autonomous, nearby non-tumor cells, and reciprocal signaling in pancreatic ductal adenocarcinoma (PDAC; an extremely heterocellular malignancy composed of mutated tumor cells, stromal fibroblasts, endothelial cells and immune cells). The gene discussed is KRAS; the disease is neoplasm.