Chang and colleagues investigated the dynamics of N-glycoproteome in plasma samples from patients with HCC, cholangiocarcinoma (CCA), or combined HCC and CCA (cHCC-CCA) to find potential biomarkers related to disease diagnosis and progression; totally 57 differentially expressed proteins were identified, of those, C3 and APOC3 proteins were associated with the tumor stage, tumor grade, recurrence-free survival and overall survival of HCC. The gene discussed is C3; the disease is hepatocellular carcinoma.