PPARβ/δ is also capable of regulating NF–κB. The activation of PPARβ/δ protects skeletal muscle against metabolic disorders also by means of counteracting the diet–induced activation of NF–κB as well as expression of iNOS and intercellular–adhesion–molecule–1 (ICAM–1) [572]. This evidence concerns the gene NFKB1 and Other metabolic disease.