PIK3CD and cancer: Another interesting basket trial is the NCI-MPACT (the NCI’s Molecular Profiling-Based Assignment of Cancer Therapy), a phase II study for advanced refractory solid tumors which are tested for 20 genes belonging to three molecular pathways broadly known to be involved in tumorigenesis -MAPK, PI3K and DNA repair- and then randomized 2:1 to different therapies depending on the mutation found.