MAPK8 and rheumatoid arthritis: IL-17 stimulation also results in the induction of C-C motif chemokine ligand 2/monocyte chemoattractant protein 1, the monocyte chemoattractant mediating monocyte migration from the blood to synovial tissue, and the process involves the activation of the JNK pathway in RA synovial fibroblasts [65].