DUSP22 and Autoimmunity: Somewhat different from the effect of DUSP1 KO, aged mice with DUSP22 deficiency spontaneously develop inflammation and autoimmunity manifesting with elevated circulating levels of antinuclear antibodies and antidouble-stranded DNA antibodies, together with reductions in the levels of proinflammatory cytokines, such as IFN-γ, IL-17, IL-6, and TNF-α in the serum, compared with young DUSP22-KO mice [108].