PARP1 and colorectal carcinoma: Because PARP-1 mediates parthanatos when it is overactivated, we investigated the role of PARP-1 in CLytA-DAAO-induced cell death, pretreating pancreatic and colorectal carcinoma cell lines with 3,4-Dihydro-5(4-(1-piperindinyl)butoxy)-1(2H)-isoquinoline (DPQ), a PARP inhibitor [17,18].