AKT1 and cancer: Whether InsP6 exerts its anti-cancer activity by interfering with PIs-mediated activation of proteins is not established, as it has been reported that its inhibition of cancer cell proliferation, cancer cell survival and metastasis [64,74,75] is a result of inhibition of several pathways, including the phosphoinositide 3-kinase [PI3K)/Akt pathway [67,73,76].