In the study by Drliceck et al. [39], a combination of antibodies against different CK for epithelial markers (AE1/AE3 (a keratin cocktail that detects CK1-8, CK10, CK14–16, and CK19); CK7, CK10/13, CK18, and CK20), vimentin (epithelial cancers), protein S100 (melanoma), TTF-1 (lung), CA 15-3 (breast), CA19.9, CA125, and PSA was used to identify the primary origin of BM. The gene discussed is VIM; the disease is melanoma.