Giordana et al. [5] analysed 99 patients with BM as the first manifestation of cancer using antibodies to carcinoembryonic antigen (CEA) for gastrointestinal or lung cancer, carbohydrate antigen (CA)19.9 for gastrointestinal cancer, cytokeratin (CK) 20 for colon cancer, CA125 for ovarian cancer, BCA-225 for breast cancer, PSA for prostatic cancer, and HMB-45 for melanoma. The gene discussed is CEACAM5; the disease is melanoma.