It was found that NS1619 could selectively modulate the protein expression of caveolin-1 through ROS/PI3K/PKB/FoxO1 signaling in brain capillary endothelial cells in tumor area of rat brain glioma (C6) model in a time dependent fashion, resulting in increased caveolae-mediated cholera toxin subunit B endocytosis into tumor microvessels [65] (Figure 2). This evidence concerns the gene FOXO1 and neoplasm.