In addition to dimethyl fumarate, Nrf2 activators such as curcumin, resveratrol, sulforaphane, masatinib, methylene blue, omaveloxolone, tideglusib, Dl-3-n-butylphthalide ide, ALKS-8700, benfotiamine, and ketogenic diet undergoing clinical trials for treating various neurodegenerative disease such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Friedreich’s ataxia, multiple sclerosis, amyotrophic lateral sclerosis, cataract, schizophrenia, bipolar disorder, mild cognitive impairment, depression, autism, obstructive sleep apnea, etc. [59]. The gene discussed is NFE2L2; the disease is Parkinson disease.