BRCA1 and pancreatic neoplasm: The only phase III trial has been conducted in the maintenance setting and is the international, randomized, placebo-controlled POLO (Pancreas cancer OLaparib Ongoing) trial, in which patients with metastatic pancreatic cancer and a germline BRCA1 and/or BRCA2 mutation whose disease had not progressed on first-line platinum-based chemotherapy derived a statistically significant and clinically meaningful improvement in progression-free survival (PFS; primary endpoint of the study) from maintenance treatment with PARP inhibitor olaparib vs. placebo.