In an effort to at least in part fill this gap, Silvestri et al. recently analyzed a large dataset of males harboring a germline mutation in the BRCA1 or BRCA2 gene, showing that being affected by any tumor and developing multiple cancers, particularly those of the breast, prostate and pancreas, is linked to a higher probability of being a BRCA2, rather than a BRCA1, carrier [12]. This evidence concerns the gene BRCA2 and neoplasm.