P2RX3 and endometriosis: It is known that P2X3 receptor, expressed in sensory neurons, mediates nociceptive, neuropathic, and inflammatory pain, and it is enrolled in endometriosis-related pain; therefore, pharmacological P2X3 inhibition is a worthy candidate for testing; in this sense, the use of the P2X3 receptor antagonist gefapixant is under clinical study.