After merging multiple datasets, we identified a total of 16,651 CD8+ and 14,036 CD4+ TILs and based on the gene expression of functional markers related to recent T cell activation (see Section 4.6) determined the proportion of tumor-reactive CD8+ TILs (Figure 2A) or CD4+ TILs (Figure 2B and Figure S5B) in MM versus non-MM epithelial samples, the proportion of tumor-reactive CD8+ versus CD4+ TILs (Figure 2C), and the correlation in the proportion of tumor-reactive CD8+ and CD4+ TILs in each sample (Figure 2D). This evidence concerns the gene CD4 and neoplasm.