Indeed, Herrnberger et al. demonstrated that mice lacking liver sinusoidal fenestrations due to genetic deletion of plasmalemma vesicle-associated protein (PLVAP), an endothelial-specific membrane glycoprotein, developed extensive hepatic steatohepatitis along with severe hyperlipoproteinemia under normal chow-fed conditions [20]. This evidence concerns the gene PLVAP and hyperlipoproteinemia.