Furthermore, LSEC secrete in response to lipotoxic treatment, among other insults, various chemokines including C-C motif chemokine ligand (CCL) 1, CCL2, CCL25, and several chemotactic (C-X-C motif) ligands, which can drive the recruitment of leukocytes into the liver parenchyma, a critical step in NASH progression (Figure 3) [54,55]. The gene discussed is CCL2; the disease is metabolic dysfunction-associated steatohepatitis.