Nevertheless, in another study, TP53 mutations (most of which were missense-producing non-functional proteins) were identified in cfDNA of 11.4% (14/123) of healthy donors compared to 49% of small cell lung cancer (SCLC) patients and this result was further validated in an independent cohort of healthy donors (11/102) with similar (10.8%) mutation frequency [29]. The gene discussed is TP53; the disease is small cell lung carcinoma.