IFNG and chronic mucocutaneous candidiasis: Similarly, autoantibodies against IL-17 and IL-22 can result in clinical pictures indistinguishable from chronic mucocutaneous candidiasis, an AR disease caused by mutations in genes encoding cytokines, such as IL-17 and IL-22, involved in immune response against fungal infections [51], whereas autoantibodies against IFN-γ can result in clinical manifestations (e.g., opportunistic infections) similar to those seen in patients who have genetic defects in the IL-12/IFN-γ axis.