In 2019, another meta-analysis investigating IL-6 to differentiate between infection and non-infection in critically ill patients included six studies with 527 ICU patients, and reported a pooled sensitivity and specificity of 0.73 (95% CI, 0.61–0.82) and 0.76 (95% CI, 0.61–0.87), respectively [34]. This evidence concerns the gene IL6 and infection.