EGFR and lung cancer: In this regard, one of the recent developments is in the field of superparamagnetic iron oxide (SPIO) nanoparticles (40–50 nm), whereby polyethylene glycol-coated SPIO nanoparticles (PEG-SPIO) were synthesized and further labeled with high affinity anti-EGFR monoclonal antibody (cetuximab) for targeted delivery to lung cancer that overexpresses EGFR [30].