Borner et al. examined the expression of the p53 and Bcl-2 family proteins in 49 specimens of patients with NSCLC via immunostaining, showing a negative influence of Bcl-2 expression on relapse-free survival (p = 0.02), while the expression of p53 and Bcl-2 was significantly associated with metastasis-free survival (p < 0.01) [69]. The gene discussed is TP53; the disease is non-small cell lung carcinoma.