EPHX1 and acute myeloid leukemia: Recently, EPHX1 (microsomal epoxide hydrolase 1), encoding for a genotoxic epoxides detoxifying enzyme, has been linked to susceptibility of AML cells to anthracycline treatment via regulation of cytochrome P450 isophormes (CYP1A1) and other drug-metabolizing enzymes (such as glutathione S-transferase) and apoptotic signaling (BCL-2) [51].