MUC1 and familial pancreatic carcinoma: Gunda et al. [5] reported the role of MUC1-mediated metabolism in imparting the resistance to radiation therapy in PDAC and found that MUC1 decreased the radiation-induced cytotoxicity and DNA damage in pancreatic cancer cells (S2−013 and Capan2) by enhancing glycolysis, pentose phosphate pathway, and nucleotide biosynthesis (Figure 1).