Increased expression of Arg1 and IL-4, with alternatively activated macrophage infiltration in a KRASG12D p53R172H Pdx-Cre+/+ (KPC)-mouse model of cachexia, was found to have a negative correlation between CD163-positive macrophage infiltration and cachexia phenotype in mice, thus suggesting the role of TAMs (via increasing expression of ARG1) and ARG1 in the pathogenesis of PDAC and PDAC associated cachexia [117,118]. The gene discussed is ARG1; the disease is Cachexia.