Autophagy can be suppressed by melanoma-associated antigen family A (MAGEA6) in PDAC cells (AsPC-1, BxPC-3, Capan-1, Capan-2, Panc-1, and MIA PaCa-2) and this suppression is released upon MAGEA6 degradation induced by nutrient deficiency or by the acquisition of cancer-associated mutations. The gene discussed is MAGEA6; the disease is cancer.