ESR1 and breast carcinoma: Weng JR et al. also found that 3β, 7β-dihydroxy-25-methoxycucurbita-5,23-diene-19-al (DMC) can induce PPARγ activation and suppress some PPARγ-targeted signals, including cyclin D1, CDK6, Bcl-2, XIAP, cyclooxygenase-2, NF-κB, and estrogen receptor α, in breast cancer cells [40].