1B). As Interleukins play important roles in immune response, we also investigated the mRNA expression of all Interleukin families. IL11RA and IL17RB were decreased in obesity group, whereas IL19 and IL25 were increased (Supplementary Figure 1C). Among them, low expression of IL11RA also indicated improved OS (Supplementary Figure 1D). This evidence concerns the gene IL25 and obesity due to melanocortin 4 receptor deficiency.