CASP1 and COVID-19: Also important to consider, while normal physiological “mild” activation of the Nlrp3 inflammasome is crucial to maintaining the trafficking of HSPCs, its hyperactivation may lead to caspase-1-mediated cell death by pyroptosis, as seen for example during a cytokine storm in COVID19-infected patients or in complications of CAR-T cell therapy [48, 49].