Thinking about the upregulation of HO-1 expression as a potential anti-metastatic treatment, we have to consider other effects of HO-1 that promote the growth of cancer cells .Specifically, HO-1 reportedly plays a role in cancer progression, and its expression in cancer cells correlates with enhanced tumor growth, metastatic and angiogenic potential, resistance to chemotherapy, tumor escape, and poor prognosis [46]. Here, HMOX1 is linked to cancer.