SOX2 and cancer: Similar findings have been shown in the context of endogenous chromatin in cancer cells in vivo, as in the case for ZF-KRAB targeting the SOX2 gene (79) and ZF-DNMT3A targeting the MASPIN (80) and SOX2 genes (80,81), thereby corroborating the longevity of epigenetic silencing via de novo DNAme and consequent inhibition of tumor growth.