Furthermore, the combination of TET1-CD (catalyzing DNA demethylation) with Base excision repair (BER) enzymes (e.g., GADD45A or NEIL2) using the SpdCas9 Casilio recruiting system (67), or TET1-CD and VP64, simultaneously recruited by an optimized single gRNA/SpdCas9-SunTag platform, also enhanced the upregulation of several hypermethylated genes in a lung adenocarcinoma cell line (247). Here, TET1 is linked to lung adenocarcinoma.