PMEPA1 was found highly expressed in the lung cancer cell lines,whereas knockdown of PMEPA1 could significantly inhibit the proliferation of cancercells (Vo Nguyen et al., 2014).Overexpression of PMEPA1 was associated with poor prognosis of lung cancer, whichwas in line with our findings. The gene discussed is PMEPA1; the disease is lung carcinoma.