RAD51 and neoplasm: Herein, we examined the HRR response in MDA-MB-231, being unresponsive to SG, including upregulation of Rad51 and levels of dsDNA breaks mediated by SG exposure, and compared it to that of SG-sensitive tumor lines (SK-MES-1 and HCC1806) to elucidate the role that this pathway plays in protecting cells from SG-mediated dsDNA breaks.